Thermodynamic Coupling - Free Energy Calculations of Correlated Amino Acid Mutations
نویسندگان
چکیده
منابع مشابه
Correlated Mutations: A Hallmark of Phenotypic Amino Acid Substitutions
Point mutations resulting in the substitution of a single amino acid can cause severe functional consequences, but can also be completely harmless. Understanding what determines the phenotypical impact is important both for planning targeted mutation experiments in the laboratory and for analyzing naturally occurring mutations found in patients. Common wisdom suggests using the extent of evolut...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2019
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2018.11.2501